In statistics and machine learning, a Markov blanket of a random variable is a set of variables that renders the variable conditionally independent of all other variables in the system. This concept is central in probabilistic graphical models and feature selection. If a Markov blanket is minimal—meaning that no variable in it can be removed without losing this conditional independence—it is called a Markov boundary. Identifying a Markov blanket or boundary allows for efficient inference and helps isolate relevant variables for prediction or causal reasoning. The terms Markov blanket and Markov boundary were coined by Judea Pearl in 1988. A Markov blanket may be derived from the structure of a probabilistic graphical model such as a Bayesian network or Markov random field. == Definition == A Markov blanket of a random variable Y {\displaystyle Y} in a random variable set S = { X 1 , … , X n } {\displaystyle {\mathcal {S}}=\{X_{1},\ldots ,X_{n}\}} is any subset S 1 {\displaystyle {\mathcal {S}}_{1}} of S {\displaystyle {\mathcal {S}}} , conditioned on which other variables are independent with Y {\displaystyle Y} : Y ⊥ ⊥ S ∖ S 1 ∣ S 1 {\displaystyle Y\perp \!\!\!\perp {\mathcal {S}}\smallsetminus {\mathcal {S}}_{1}\mid {\mathcal {S}}_{1}} It means that S 1 {\displaystyle {\mathcal {S}}_{1}} contains at least all the information one needs to infer Y {\displaystyle Y} , where the variables in S ∖ S 1 {\displaystyle {\mathcal {S}}\smallsetminus {\mathcal {S}}_{1}} are redundant. In general, a given Markov blanket is not unique. Any set in S {\displaystyle {\mathcal {S}}} that contains a Markov blanket is also a Markov blanket itself. Specifically, S {\displaystyle {\mathcal {S}}} is a Markov blanket of Y {\displaystyle Y} in S {\displaystyle {\mathcal {S}}} . === Example === In a Bayesian network, the Markov blanket of a node consists of its parents, its children, and its children's other parents (i.e., co-parents). Knowing the values of these nodes makes the target node conditionally independent of the rest of the network. In a Markov random field, the Markov blanket of a node is simply its immediate neighbors. == Markov condition == The concept of a Markov blanket is rooted in the Markov condition, which states that in a probabilistic graphical model, each variable is conditionally independent of its non-descendants given its parents. This condition implies the existence of a minimal separating set — the Markov blanket — that shields a variable from the rest of the network. For instance, when a person holds an object stationary against gravity, the object’s acceleration is fully determined by its direct causes—namely, the upward force from the hand and the downward gravitational pull. Other variables such as air pressure or temperature are causally irrelevant. == Markov boundary == A Markov boundary of Y {\displaystyle Y} in S {\displaystyle {\mathcal {S}}} is a subset S 2 {\displaystyle {\mathcal {S}}_{2}} of S {\displaystyle {\mathcal {S}}} , such that S 2 {\displaystyle {\mathcal {S}}_{2}} itself is a Markov blanket of Y {\displaystyle Y} , but any proper subset of S 2 {\displaystyle {\mathcal {S}}_{2}} is not a Markov blanket of Y {\displaystyle Y} . In other words, a Markov boundary is a minimal Markov blanket. The Markov boundary of a node A {\displaystyle A} in a Bayesian network is the set of nodes composed of A {\displaystyle A} 's parents, A {\displaystyle A} 's children, and A {\displaystyle A} 's children's other parents. In a Markov random field, the Markov boundary for a node is the set of its neighboring nodes. In a dependency network, the Markov boundary for a node is the set of its parents. === Uniqueness of Markov boundary === The Markov boundary always exists. Under some mild conditions, the Markov boundary is unique. However, for most practical and theoretical scenarios multiple Markov boundaries may provide alternative solutions. When there are multiple Markov boundaries, quantities measuring causal effect could fail. == In cognitive science == In the study of consciousness, brain function, and complex adaptive systems, Markov blankets are proposed as a mathematical mechanism which delimits the extent of cognitive entities, whether it be physical or causal.
Docic
Docic is a Tunisian digital health platform available as a web and mobile application, headquartered in Tunis, Tunisia. Founded in 2022 by Sami Kallel, an orthopedic surgeon, and Sofiane Trabelsi. The service helps patients and healthcare professionals store, organize, and share medical records digitally and to connect with the doctor online. == History == Docic was founded in 2022 as a health-technology company based in Tunisia, after which the mobile application was subsequently developed and made available to users. The platform was designed to provide healthcare professionals with access to patients’ complete medical history, including updates and recent changes, aiming at supporting clinical decision-making and reducing the risk of medical errors. In January 2025, Docic was listed amongst companies that have received the Startup Act label, which is a recognition under the Tunisian legal framework made to support innovative startups.
Grammatical evolution
Grammatical evolution (GE) is a genetic programming (GP) technique (or approach) from evolutionary computation pioneered by Conor Ryan, JJ Collins and Michael O'Neill in 1998 at the BDS Group in the University of Limerick. As in any other GP approach, the objective is to find an executable program, program fragment, or function, which will achieve a good fitness value for a given objective function. In most published work on GP, a LISP-style tree-structured expression is directly manipulated, whereas GE applies genetic operators to an integer string, subsequently mapped to a program (or similar) through the use of a grammar, which is typically expressed in Backus–Naur form. One of the benefits of GE is that this mapping simplifies the application of search to different programming languages and other structures. == Problem addressed == In type-free, conventional Koza-style GP, the function set must meet the requirement of closure: all functions must be capable of accepting as their arguments the output of all other functions in the function set. Usually, this is implemented by dealing with a single data-type such as double-precision floating point. While modern Genetic Programming frameworks support typing, such type-systems have limitations that Grammatical Evolution does not suffer from. == GE's solution == GE offers a solution to the single-type limitation by evolving solutions according to a user-specified grammar (usually a grammar in Backus-Naur form). Therefore, the search space can be restricted, and domain knowledge of the problem can be incorporated. The inspiration for this approach comes from a desire to separate the "genotype" from the "phenotype": in GP, the objects the search algorithm operates on and what the fitness evaluation function interprets are one and the same. In contrast, GE's "genotypes" are ordered lists of integers which code for selecting rules from the provided context-free grammar. The phenotype, however, is the same as in Koza-style GP: a tree-like structure that is evaluated recursively. This model is more in line with how genetics work in nature, where there is a separation between an organism's genotype and the final expression of phenotype in proteins, etc. Separating genotype and phenotype allows a modular approach. In particular, the search portion of the GE paradigm needn't be carried out by any one particular algorithm or method. Observe that the objects GE performs search on are the same as those used in genetic algorithms. This means, in principle, that any existing genetic algorithm package, such as the popular GAlib, can be used to carry out the search, and a developer implementing a GE system need only worry about carrying out the mapping from list of integers to program tree. It is also in principle possible to perform the search using some other method, such as particle swarm optimization (see the remark below); the modular nature of GE creates many opportunities for hybrids as the problem of interest to be solved dictates. Brabazon and O'Neill have successfully applied GE to predicting corporate bankruptcy, forecasting stock indices, bond credit ratings, and other financial applications. GE has also been used with a classic predator-prey model to explore the impact of parameters such as predator efficiency, niche number, and random mutations on ecological stability. It is possible to structure a GE grammar that for a given function/terminal set is equivalent to genetic programming. == Criticism == Despite its successes, GE has been the subject of some criticism. One issue is that as a result of its mapping operation, GE's genetic operators do not achieve high locality which is a highly regarded property of genetic operators in evolutionary algorithms. == Variants == Although GE was originally described in terms of using an Evolutionary Algorithm, specifically, a Genetic Algorithm, other variants exist. For example, GE researchers have experimented with using particle swarm optimization to carry out the searching instead of genetic algorithms with results comparable to that of normal GE; this is referred to as a "grammatical swarm"; using only the basic PSO model it has been found that PSO is probably equally capable of carrying out the search process in GE as simple genetic algorithms are. (Although PSO is normally a floating-point search paradigm, it can be discretized, e.g., by simply rounding each vector to the nearest integer, for use with GE.) Yet another possible variation that has been experimented with in the literature is attempting to encode semantic information in the grammar in order to further bias the search process. Other work showed that, with biased grammars that leverage domain knowledge, even random search can be used to drive GE. == Related work == GE was originally a combination of the linear representation as used by the Genetic Algorithm for Developing Software (GADS) and Backus Naur Form grammars, which were originally used in tree-based GP by Wong and Leung in 1995 and Whigham in 1996. Other related work noted in the original GE paper was that of Frederic Gruau, who used a conceptually similar "embryonic" approach, as well as that of Keller and Banzhaf, which similarly used linear genomes. == Implementations == There are several implementations of GE. These include the following.
Receptron
The receptron (short for "reservoir perceptron") is a neuromorphic data processing model — specifically neuromorphic computing — that generalizes the traditional perceptron, by incorporating non-linear interactions between inputs. Unlike classical perceptron, which rely on linearly independent weights, the receptron leverages complexity in physical substrates, such as the electric conduction properties of nanostructured materials or optical speckle fields, to perform classification tasks. The receptron bridges unconventional computing and neural network principles, enabling solutions that do not require the training approaches typical of artificial neural networks based on the perceptron model. == Algorithm == The receptron is an algorithm for supervised learning of binary classifiers, so a classification algorithm that makes its predictions based on a predictor function, combining a set of weights with the feature vector. The mathematical model is based on the sum of inputs with non-linear interactions: S = ∑ k = 1 n x j w ~ j ( x → ) | S ∈ R {\displaystyle S=\sum _{k=1}^{n}x_{j}{\widetilde {w}}_{j}({\vec {x}})|S\in R} (1) where j ∈ [ 1 , n ] {\displaystyle j\in [1,n]} and w ~ j {\displaystyle {\widetilde {w}}_{j}} are non-linear weight functions depending on the inputs, x → {\displaystyle {\vec {x}}} . Nonlinearity will typically make the system extremely complex, and allowing for the solution of problems not solvable through the simpler rules of a linear system, such as the perceptron or McCulloch Pitts neurons, which is based on the sum of linearly independent weights: S = ∑ k = 1 n x j w j p {\displaystyle S=\sum _{k=1}^{n}x_{j}w_{j}^{p}} (2) where w j {\displaystyle w_{j}} are constant real values. A consequence of this simplicity is the limitation to linearly separable functions, which necessitates multi-layer architectures and training algorithms like backpropagation As in the perceptron case, the summation in Eq. 1 origins the activation of the receptron output through the thresholding process, Y ( x 1 , . . . , x n ) = { 1 if S > th 0 if S ≤ th {\displaystyle Y(x_{1},...,x_{n})={\begin{cases}1&{\text{if }}S>{\text{th}}\\0&{\text{if }}S\leq {\text{th}}\end{cases}}} (3) where th is a constant threshold parameter. Equation 3 can be written by using the Heaviside step function. The weight functions w ~ ( x → ) {\displaystyle {\widetilde {w}}({\vec {x}})} can be written with a finite number of parameters w j 1 . . . j n {\displaystyle w_{j_{1}...j_{n}}} , simplifying the model representation. One can Taylor-expand w ~ ( x → ) {\displaystyle {\widetilde {w}}({\vec {x}})} and use the idempotency of Boolean variables ( x j ) q = x j ∀ q ≥ 1 {\displaystyle (x_{j})^{q}=x_{j}\forall q\geq 1} such that S ′ = b + ∑ k = 1 n x j w ~ j ( x → ) {\displaystyle S'=b+\sum _{k=1}^{n}x_{j}{\widetilde {w}}_{j}({\vec {x}})} can be written as S ′ ( x → ) = b + ∑ j w j x j + ∑ j < k w j k x j x k + ∑ j < k < l w j k l x j x k x l + . . . {\displaystyle S'({\vec {x}})=b+\sum _{j}w_{j}x_{j}+\sum _{j In signal processing, independent component analysis (ICA) is a computational method for separating a multivariate signal into additive subcomponents. This is done by assuming that at most one subcomponent is Gaussian and that the subcomponents are statistically independent from each other. ICA was invented by Jeanny Hérault and Christian Jutten in 1985. ICA is a special case of blind source separation. A common example application of ICA is the "cocktail party problem" of listening in on one person's speech in a noisy room. == Introduction == Independent component analysis attempts to decompose a multivariate signal into independent non-Gaussian signals. As an example, sound is usually a signal that is composed of the numerical addition, at each time t, of signals from several sources. The question then is whether it is possible to separate these contributing sources from the observed total signal. When the statistical independence assumption is correct, blind ICA separation of a mixed signal gives very good results. It is also used for signals that are not supposed to be generated by mixing for analysis purposes. A simple application of ICA is the "cocktail party problem", where the underlying speech signals are separated from a sample data consisting of people talking simultaneously in a room. Usually the problem is simplified by assuming no time delays or echoes. Note that a filtered and delayed signal is a copy of a dependent component, and thus the statistical independence assumption is not violated. Mixing weights for constructing the M {\textstyle M} observed signals from the N {\textstyle N} components can be placed in an M × N {\textstyle M\times N} matrix. An important thing to consider is that if N {\textstyle N} sources are present, at least N {\textstyle N} observations (e.g. microphones if the observed signal is audio) are needed to recover the original signals. When there are an equal number of observations and source signals, the mixing matrix is square ( M = N {\textstyle M=N} ). Other cases of underdetermined ( M < N {\textstyle M Application performance engineering is a method to develop and test application performance in various settings, including mobile computing, the cloud, and conventional information technology (IT). == Methodology == According to the American National Institute of Standards and Technology, nearly four out of every five dollars spent on the total cost of ownership of an application is directly attributable to finding and fixing issues post-deployment. A full one-third of this cost could be avoided with better software testing. Application performance engineering attempts to test software before it is published. While practices vary among organizations, the method attempts to emulate the real-world conditions that software in development will confront, including network deployment and access by mobile devices. Techniques include network virtualization. An artificial neural network (ANN) or neural network combines biological principles with advanced statistics to solve problems in domains such as pattern recognition and game-play. ANNs adopt the basic model of neuron analogues connected to each other in a variety of ways. == Structure == === Neuron === A neuron with label j {\displaystyle j} receiving an input p j ( t ) {\displaystyle p_{j}(t)} from predecessor neurons consists of the following components: an activation a j ( t ) {\displaystyle a_{j}(t)} , the neuron's state, depending on a discrete time parameter, an optional threshold θ j {\displaystyle \theta _{j}} , which stays fixed unless changed by learning, an activation function f {\displaystyle f} that computes the new activation at a given time t + 1 {\displaystyle t+1} from a j ( t ) {\displaystyle a_{j}(t)} , θ j {\displaystyle \theta _{j}} and the net input p j ( t ) {\displaystyle p_{j}(t)} giving rise to the relation a j ( t + 1 ) = f ( a j ( t ) , p j ( t ) , θ j ) , {\displaystyle a_{j}(t+1)=f(a_{j}(t),p_{j}(t),\theta _{j}),} and an output function f out {\displaystyle f_{\text{out}}} computing the output from the activation o j ( t ) = f out ( a j ( t ) ) . {\displaystyle o_{j}(t)=f_{\text{out}}(a_{j}(t)).} Often the output function is simply the identity function. An input neuron has no predecessor but serves as input interface for the whole network. Similarly an output neuron has no successor and thus serves as output interface of the whole network. === Propagation function === The propagation function computes the input p j ( t ) {\displaystyle p_{j}(t)} to the neuron j {\displaystyle j} from the outputs o i ( t ) {\displaystyle o_{i}(t)} and typically has the form p j ( t ) = ∑ i o i ( t ) w i j . {\displaystyle p_{j}(t)=\sum _{i}o_{i}(t)w_{ij}.} === Bias === A bias term can be added, changing the form to the following: p j ( t ) = ∑ i o i ( t ) w i j + w 0 j , {\displaystyle p_{j}(t)=\sum _{i}o_{i}(t)w_{ij}+w_{0j},} where w 0 j {\displaystyle w_{0j}} is a bias. == Neural networks as functions == Neural network models can be viewed as defining a function that takes an input (observation) and produces an output (decision) f : X → Y {\displaystyle \textstyle f:X\rightarrow Y} or a distribution over X {\displaystyle \textstyle X} or both X {\displaystyle \textstyle X} and Y {\displaystyle \textstyle Y} . Sometimes models are intimately associated with a particular learning rule. A common use of the phrase "ANN model" is really the definition of a class of such functions (where members of the class are obtained by varying parameters, connection weights, or specifics of the architecture such as the number of neurons, number of layers or their connectivity). Mathematically, a neuron's network function f ( x ) {\displaystyle \textstyle f(x)} is defined as a composition of other functions g i ( x ) {\displaystyle \textstyle g_{i}(x)} , that can further be decomposed into other functions. This can be conveniently represented as a network structure, with arrows depicting the dependencies between functions. A widely used type of composition is the nonlinear weighted sum, where f ( x ) = K ( ∑ i w i g i ( x ) ) {\displaystyle \textstyle f(x)=K\left(\sum _{i}w_{i}g_{i}(x)\right)} , where K {\displaystyle \textstyle K} (commonly referred to as the activation function) is some predefined function, such as the hyperbolic tangent, sigmoid function, softmax function, or rectifier function. The important characteristic of the activation function is that it provides a smooth transition as input values change, i.e. a small change in input produces a small change in output. The following refers to a collection of functions g i {\displaystyle \textstyle g_{i}} as a vector g = ( g 1 , g 2 , … , g n ) {\displaystyle \textstyle g=(g_{1},g_{2},\ldots ,g_{n})} . This figure depicts such a decomposition of f {\displaystyle \textstyle f} , with dependencies between variables indicated by arrows. These can be interpreted in two ways. The first view is the functional view: the input x {\displaystyle \textstyle x} is transformed into a 3-dimensional vector h {\displaystyle \textstyle h} , which is then transformed into a 2-dimensional vector g {\displaystyle \textstyle g} , which is finally transformed into f {\displaystyle \textstyle f} . This view is most commonly encountered in the context of optimization. The second view is the probabilistic view: the random variable F = f ( G ) {\displaystyle \textstyle F=f(G)} depends upon the random variable G = g ( H ) {\displaystyle \textstyle G=g(H)} , which depends upon H = h ( X ) {\displaystyle \textstyle H=h(X)} , which depends upon the random variable X {\displaystyle \textstyle X} . This view is most commonly encountered in the context of graphical models. The two views are largely equivalent. In either case, for this particular architecture, the components of individual layers are independent of each other (e.g., the components of g {\displaystyle \textstyle g} are independent of each other given their input h {\displaystyle \textstyle h} ). This naturally enables a degree of parallelism in the implementation. Networks such as the previous one are commonly called feedforward, because their graph is a directed acyclic graph. Networks with cycles are commonly called recurrent. Such networks are commonly depicted in the manner shown at the top of the figure, where f {\displaystyle \textstyle f} is shown as dependent upon itself. However, an implied temporal dependence is not shown. == Backpropagation == Backpropagation training algorithms fall into three categories: steepest descent (with variable learning rate and momentum, resilient backpropagation); quasi-Newton (Broyden–Fletcher–Goldfarb–Shanno, one step secant); Levenberg–Marquardt and conjugate gradient (Fletcher–Reeves update, Polak–Ribiére update, Powell–Beale restart, scaled conjugate gradient). === Algorithm === Let N {\displaystyle N} be a network with e {\displaystyle e} connections, m {\displaystyle m} inputs and n {\displaystyle n} outputs. Below, x 1 , x 2 , … {\displaystyle x_{1},x_{2},\dots } denote vectors in R m {\displaystyle \mathbb {R} ^{m}} , y 1 , y 2 , … {\displaystyle y_{1},y_{2},\dots } vectors in R n {\displaystyle \mathbb {R} ^{n}} , and w 0 , w 1 , w 2 , … {\displaystyle w_{0},w_{1},w_{2},\ldots } vectors in R e {\displaystyle \mathbb {R} ^{e}} . These are called inputs, outputs and weights, respectively. The network corresponds to a function y = f N ( w , x ) {\displaystyle y=f_{N}(w,x)} which, given a weight w {\displaystyle w} , maps an input x {\displaystyle x} to an output y {\displaystyle y} . In supervised learning, a sequence of training examples ( x 1 , y 1 ) , … , ( x p , y p ) {\displaystyle (x_{1},y_{1}),\dots ,(x_{p},y_{p})} produces a sequence of weights w 0 , w 1 , … , w p {\displaystyle w_{0},w_{1},\dots ,w_{p}} starting from some initial weight w 0 {\displaystyle w_{0}} , usually chosen at random. These weights are computed in turn: first compute w i {\displaystyle w_{i}} using only ( x i , y i , w i − 1 ) {\displaystyle (x_{i},y_{i},w_{i-1})} for i = 1 , … , p {\displaystyle i=1,\dots ,p} . The output of the algorithm is then w p {\displaystyle w_{p}} , giving a new function x ↦ f N ( w p , x ) {\displaystyle x\mapsto f_{N}(w_{p},x)} . The computation is the same in each step, hence only the case i = 1 {\displaystyle i=1} is described. w 1 {\displaystyle w_{1}} is calculated from ( x 1 , y 1 , w 0 ) {\displaystyle (x_{1},y_{1},w_{0})} by considering a variable weight w {\displaystyle w} and applying gradient descent to the function w ↦ E ( f N ( w , x 1 ) , y 1 ) {\displaystyle w\mapsto E(f_{N}(w,x_{1}),y_{1})} to find a local minimum, starting at w = w 0 {\displaystyle w=w_{0}} . This makes w 1 {\displaystyle w_{1}} the minimizing weight found by gradient descent. == Learning pseudocode == To implement the algorithm above, explicit formulas are required for the gradient of the function w ↦ E ( f N ( w , x ) , y ) {\displaystyle w\mapsto E(f_{N}(w,x),y)} where the function is E ( y , y ′ ) = | y − y ′ | 2 {\displaystyle E(y,y')=|y-y'|^{2}} . The learning algorithm can be divided into two phases: propagation and weight update. === Propagation === Propagation involves the following steps: Propagation forward through the network to generate the output value(s) Calculation of the cost (error term) Propagation of the output activations back through the network using the training pattern target to generate the deltas (the difference between the targeted and actual output values) of all output and hidden neurons. === Weight update === For each weight: Multiply the weight's output delta and input activation to find the gradient of the weight. Subtract the ratio (percentage) of the weight's gradient from the weight. The learning rate is the ratio (percentage) that influences the speed and quality of learning. The greater the ratio, the faster the neuron trains, but the lower the ratio, the more accuratIndependent component analysis
Application performance engineering
Mathematics of neural networks in machine learning